Journal article
Reassessment of amphetamine- and phencyclidine-induced locomotor hyperactivity as a model of psychosis-like behavior in rats
S Kusljic, M van den Buuse, A Gogos
Journal of Integrative Neuroscience | Published : 2022
Abstract
Locomotor hyperactivity induced by psychotomimetic drugs, such as amphetamine and phencyclidine, is widely used as an animal model of psychosis-like behaviour and is commonly attributed to an interaction with dopamine release and N-methyl-D-aspartate (NMDA) receptors, respectively. However, what is often not sufficiently taken into account is that the pharmacological profile of these drugs is complex and may involve other neurotransmitter/receptor systems. Therefore, this study aimed to assess the effect of three antagonists targeting different monoamine pathways on amphetamine- and phencyclidine-induced locomotor hyperactivity. A total of 32 rats were pre-treated with antagonists affecting ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research was part-funded by the National Health and Medical Research Council of Australia (AG CDF 1108098, Project Grant 509234). The Florey Institute of Neuroscience and Mental Health acknowledges the funding from the Victorian Government's Operational Infrastructure Support.