Journal article
Association between amyloid-beta deposition and cortical thickness in dementia with Lewy bodies
Kai Sin Chin, Sanuji Gajamange, Patricia M Desmond, Victor L Villemagne, Christopher C Rowe, Leonid Churilov, Nawaf Yassi, Rosie Watson
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | SAGE PUBLICATIONS LTD | Published : 2023
Abstract
Objective: Amyloid-beta often co-exists in dementia with Lewy bodies, but its clinical relevance in dementia with Lewy bodies remains unclear. This study aimed to investigate the clinical and imaging correlates of amyloid-beta deposition in dementia with Lewy bodies, particularly its relationship with cortical thickness in Alzheimer’s disease–prone regions and hippocampal volume. Methods: Twenty-four participants with probable dementia with Lewy bodies underwent high-resolution magnetic resonance imaging and amyloid-beta positron emission tomography imaging using the radiotracer 18F-NAV4694. Amyloid-beta deposition was quantified and reported using the Centiloid method. Results: Amyloid-beta..
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Funding Acknowledgements
The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was funded by the Yulgilbar Alzheimer's Research Program. K.S.C. is supported by the Research Training Program Scholarship by the Australian Commonwealth Government and a PhD top-up scholarship from the Yulgilbar Alzheimer's Research Program. All funders have no role in study design, data analysis, preparation of the manuscript and decision to submit the manuscript for publication. We also thank Mr Vincent Dore from CSIRO for his support in the quantitative analysis of amyloid-beta PET data.