Journal article
Understanding the Biological Interactions of pH-Swellable Nanoparticles
SS Kermaniyan, M Chen, C Zhang, SA Smith, APR Johnston, C Such, GK Such
Macromolecular Bioscience | WILEY-V C H VERLAG GMBH | Published : 2022
Abstract
pH-responsive nanoparticles have generated significant interest for use as drug delivery systems due to their potential for inducible release at low pH. The pH variation from the bloodstream (pH 7.4) to intracellular compartments of cells called endosomes/lysosomes (pH < 5.0) has been of particular interest. However, one of the limitations with nanoparticle delivery systems is the inability to migrate out of these compartments to the cytosol or other organelles, via a process termed endosomal escape. Previous studies have postulated that pH-responsive nanoparticles can facilitate endosomal escape through a range of mechanisms including membrane interaction, pH-induced swelling, and the proto..
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Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by the Australian Research Council Discovery Project (DP180100844). The authors would like to thank Professor Eric Hanssen, Dr Andrew Leis, Dr Hamish Brown and Dr Sepideh Valimehr for the valuable discussion and guidance for the Cryo-EM and TEM imaging. Open access publishing facilitated by The University of Melbourne, as part of the Wiley - The University of Melbourne agreement via the Council of Australian University Librarians.