Journal article

Lysine methyltransferase G9a is an important modulator of trained immunity

VP Mourits, JH van Puffelen, B Novakovic, M Bruno, AV Ferreira, RJW Arts, L Groh, TO Crișan, J Zwaag, E Jentho, M Kox, P Pickkers, FL van de Veerdonk, S Weis, E Oosterwijk, SH Vermeulen, MG Netea, LAB Joosten

Clinical and Translational Immunology | Published : 2021

Abstract

Objectives: Histone methyltransferase G9a, also known as Euchromatic Histone Lysine Methyltransferase 2 (EHMT2), mediates H3K9 methylation which is associated with transcriptional repression. It possesses immunomodulatory effects and is overexpressed in multiple types of cancer. In this study, we investigated the role of G9a in the induction of trained immunity, a de facto innate immune memory, and its effects in non-muscle-invasive bladder cancer (NMIBC) patients treated with intravesical Bacillus Calmette-Guérin (BCG). Methods: EHMT2 expression was assessed upon induction of trained immunity by RNA sequencing and Western blotting. G9a inhibitor BIX-01294 was used to investigate the effect ..

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University of Melbourne Researchers

Grants

Awarded by European Research Council


Funding Acknowledgements

We thank all the healthy volunteers and patients for blood donation. MGN was supported by a Spinoza grant of the Netherlands Organization for Scientific Research and an ERC Advanced Grant (TRAIN-OLD nr. 833247). LABJ and TOC were supported by a Competitiveness Operational Programme grant of the Romanian Ministry of European Funds (HINT, P_37_762, MySMIS 103587). BN was supported by an NHMRC (Australia) Investigator Grant (no. 1173314) and Project Grant (no. 1157556). AVF was supported by an FCT (Portugal) PhD grant (PD/BD/135449/2017). SHV is supported by a grant of the Netherlands Organization for Scientific Research (NWO Vidi 91717334). EJ was supported by DFG grant GRK 1715/2.