Journal article
Opposing Effects of Prior Infection versus Prior Vaccination on Vaccine Immunogenicity against Influenza A(H3N2) Viruses
A Fox, L Carolan, V Leung, HVM Phuong, A Khvorov, M Auladell, YY Tseng, PQ Thai, I Barr, K Subbarao, LTQ Mai, HR van Doorn, SG Sullivan
Viruses | Published : 2022
DOI: 10.3390/v14030470
Abstract
Prior vaccination can alternately enhance or attenuate influenza vaccine immunogenicity and effectiveness. Analogously, we found that vaccine immunogenicity was enhanced by prior A(H3N2) virus infection among participants of the Ha Nam Cohort, Viet Nam, but was attenuated by prior vaccination among Australian Health Care Workers (HCWs) vaccinated in the same year. Here, we combined these studies to directly compare antibody titers against 35 A(H3N2) viruses spanning 1968–2018. Participants received licensed inactivated vaccines containing A/HongKong/4801/2014 (H3N2). The analysis was limited to participants aged 18–65 Y, and compared those exposed to A(H3N2) viruses circulating since 2009 by..
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Awarded by National Institutes of Health
Funding Acknowledgements
The Health Care Worker Study was funded by the Melbourne Health Grant in Aid (Grant number GIA-002-2016). The vaccine study in Ha Nam was funded by the National Health and Medical Research Council, Australia (NHMRC -1103367). Funding to support the Ha Nam Cohort has additionally been provided by the National Foundation for Science and Technology Development (NAFOSTED -108.04-2019.08) and by the Wellcome Trust (081613, 077078 and 087982). The WHO Collaborating Centre for Reference and Research on Influenza is funded by the Australian Government Department of Health. The Oxford University Clinical Research Unit -Hanoi and HR van Doorn are funded through aWellcome Africa Asia Programme grant (089276/Z/09/Z and 106680/Z/14/Z). Y.-Y. T. and A.K. receive support from an NIH Project Grant (R01AI141534).