Journal article
Clinical and Molecular Epidemiology of Human Parainfluenza Viruses 1-4 in Children from Viet Nam
M Linster, LAH Do, NNQ Minh, Y Chen, Z Zhe, TA Tuan, HM Tuan, YCF Su, HR Van Doorn, M Moorthy, GJD Smith
Scientific Reports | NATURE PORTFOLIO | Published : 2018
Abstract
HPIVs are serologically and genetically grouped into four species that account for up to 10% of all hospitalizations due to acute respiratory infection in children under the age of five. Genetic and epidemiological data for the four HPIVs derived from two pediatric cohorts in Viet Nam are presented. Respiratory samples were screened for HPIV1-4 by real-time PCR. Demographic and clinical data of patients infected with different HPIV were compared. We used a hemi-nested PCR approach to generate viral genome sequences from HPIV-positive samples and conducted a comprehensive phylogenetic analysis. In total, 170 samples tested positive for HPIV. HPIV3 was most commonly detected in our cohort and ..
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Awarded by Ministry of Health
Funding Acknowledgements
We would like to thank Carmen Butt, Ainie Zahir, Divaashini Ravichandran, and Lai Xing Yi for excellent technical assistance. This study was supported by the Duke-NUS Signature Research Programme funded by the Ministry of Health, Singapore and by research grants from the National Medical Research Council (NMRC/CIRG/1445/2016) and the Ministry of Health (MOH/CDPHRG/0012/2014), Singapore. The original studies in which the samples were collected were funded by the Wellcome Trust of Great Britain.