Journal article
Comparison of Seroconversion in Children and Adults with Mild COVID-19
ZQ Toh, J Anderson, N Mazarakis, M Neeland, RA Higgins, K Rautenbacher, K Dohle, J Nguyen, I Overmars, C Donato, S Sarkar, V Clifford, A Daley, S Nicholson, FL Mordant, K Subbarao, DP Burgner, N Curtis, JE Bines, S McNab Show all
JAMA Network Open | Published : 2022
Open access
Abstract
Importance: The immune response in children with SARS-CoV-2 infection is not well understood. Objective: To compare seroconversion in nonhospitalized children and adults with mild SARS-CoV-2 infection and identify factors that are associated with seroconversion. Design, Setting, and Participants: This household cohort study of SARS-CoV-2 infection collected weekly nasopharyngeal and throat swabs and blood samples during the acute (median, 7 days for children and 12 days for adults [IQR, 4-13] days) and convalescent (median, 41 [IQR, 31-49] days) periods after polymerase chain reaction (PCR) diagnosis for analysis. Participants were recruited at The Royal Children's Hospital, Melbourne, Austr..
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Funding Acknowledgements
This study was supported by funding for the recruitment of participants from The Royal Children's Hospital Foundation (Dr Tosif) and the Infection and Immunity Theme, Murdoch Children's Research Institute; a Career Development Fellowship from the NHMRC (Dr Licciardi); a Commonwealth Serum Laboratories (CSL) centenary fellowship (Dr Pellicci); investigator grants from the NHMRC (Drs Subbarao and Dr Burgner); funding from the Jack Ma Foundation and the A2 Milk Company (Dr Subbarao); the Australian Government Department of Health (MelbourneWorld Health Organization Collaborating Centre for Reference and Research on Influenza); the Victorian Government's Medical Research Operational Infrastructure Support Program; and the National Institute of Health for influenza and COVID-19 research (Drs Curtis and Subbarao).