Thermally Processed Diet-Induced Albuminuria, Complement Activation and Intestinal Permeability Are Attenuated by Resistant Starch in Experimental Diabetes

Abstract

Abstract Objectives The primary objective of this study was to ascertain whether thermally processed diets influence albuminuria and intestinal permeability via alterations in the complement cascade. A secondary objective was to see whether these pathological alterations could be ameliorated by a gut-targeted dietary intervention, resistant starch. Methods Six-week-old Sprague Dawley rats were randomised to receive a control (CON; AIN93G), thermally processed diet (TPD) (AIN93G baked at 160°C for 1h) or TPD with daily gavage of either 10 mg/kg/d alagebrium chloride (ALA), an inhibitor of advanced glycation end products or daily gavage of 2mg/kg/d PMX-53,  a C5a receptor inhibitor for 24 week..