Journal article
Are Current Serum and Plasma Ferritin Cut-offs for Iron Deficiency and Overload Accurate and Reflecting Iron Status? A Systematic Review
MN Garcia-Casal, SR Pasricha, RX Martinez, L Lopez-Perez, JP Peña-Rosas
Archives of Medical Research | Published : 2018
Abstract
Background: Serum or plasma ferritin concentration is recommended by WHO as a biomarker to assess iron status in individuals and populations. Methods: A systematic review was undertaken to summarise the evidence for ferritin reflecting iron status and to assess the cut-off points in different populations. Electronic databases were searched for studies evaluating ferritin concentrations compared against bone marrow aspirates for iron deficiency and to liver biopsies for risk of iron overload. Results: From 18822 records, 298 studies were assessed in full-text, including 72 studies on iron deficiency and 36 on iron overload in the quantitative analysis. All studies were observational. For iron..
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Funding Acknowledgements
This work was supported by the Evidence and Programme Guidance, Department of Nutrition for Health and Development, World Health Organization, Switzerland; the International Micronutrient Malnutrition Prevention and Control (IMMPaCt) Program, Division of Nutrition, Physical Activity and Obesity, Centers for Disease Control and Prevention, Atlanta, USA; the Bill & Melinda Gates Foundation, USA; Nutrition International (formerly Micronutrient Initiative), Ottawa, Canada; and the US Agency for International Development (USAID), Washington, USA. Donors do not fund specific guidelines and do not participate in any decision related to the guideline development process, including the composition of research questions, membership of the guideline groups, conduct and interpretation of systematic reviews, or formulation of recommendations.