Journal article
Impact of chronic lymphocytic leukaemia on melanoma outcomes: A retrospective case-control study
D Jobson, CJ McCormack, V Mar, C Tam, MA Henderson
British Journal of Haematology | Published : 2022
DOI: 10.1111/bjh.18090
Abstract
With new, effective treatments for chronic lymphocytic leukaemia (CLL) the impact of second malignancies is increasingly important. We performed a retrospective case-controlled study examining the effect of CLL and its treatment on melanoma-specific survival and recurrence. A total of 56 patients with melanoma with CLL were matched 1:1 to patients without CLL for age, date of diagnosis, gender and melanoma tumour, node, metastasis (TNM) stage. Multivariate analysis found CLL was associated with significantly worse melanoma-specific mortality (hazard ratio [HR] 2.46, 95% confidence interval [CI] 1.27–4.74, p = 0.007) and recurrence (HR 3.44, 95% CI 1.79–6.63, p < 0.001). Patients with CLL had..
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Funding Acknowledgements
Dale Jobson designed the study, collected, interpreted, cleaned, checked and analysed the data, and wrote the manuscript. Christopher J. McCormack, Constantine Tam, Michael A. Henderson designed and supervised the study as well as supervised the interpretation and analysis of the data and reviewed and approved the final version of the manuscript. Victoria Mar supervised the collection of data and reviewed and approved the final version of the manuscript. Dale Jobson completed this research work as part of a Master of Science with the University of Edinburgh. Constantine Tam is supported by the CLL Global Foundation.