Journal article
STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis
RE Dawson, V Deswaerte, AC West, K Tang, AJ West, JJ Balic, LJ Gearing, MI Saad, L Yu, Y Wu, PS Bhathal, B Kumar, JT Chakrabarti, Y Zavros, H Oshima, DM Klinman, M Oshima, P Tan, BJ Jenkins
Gut | BMJ PUBLISHING GROUP | Published : 2022
Abstract
Objective The absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of autoimmune and chronic inflammatory diseases via caspase-1-containing inflammasome complexes. However, the role of AIM2 in cancer is ill-defined. Design The expression of AIM2 and its clinical significance was assessed in human gastric cancer (GC) patient cohorts. Genetic or therapeutic manipulation of AIM2 expression and activity was performed in the genetically engineered gp130F/F spontaneous GC mouse model, as well as human GC cell line xenografts. The biological role and mechanism of action of AIM2 in gastric tumourigenesis, including its involvement in inflammasom..
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Awarded by Australian Government
Funding Acknowledgements
This work was funded by the National Health and Medical Research Council (NHMRC) of Australia (BJ), and the Operational Infrastructure Support Program by the Victorian Government of Australia. JB and AJW were supported by Australian Postgraduate Awards from the Australian Government, and ACW was supported by an NHMRC Early Career Fellowship. BJ was supported by an NHMRC Senior Medical Research Fellowship.