Distinct Neural Profiles of Frontoparietal Networks in Boys with ADHD and Boys with Persistent Depressive Disorder

V Vilgis; D Yee; TJ Silk; A Vance

Journal article

Distinct Neural Profiles of Frontoparietal Networks in Boys with ADHD and Boys with Persistent Depressive Disorder

V Vilgis, D Yee, TJ Silk, A Vance

Cognitive Affective and Behavioral Neuroscience | SPRINGER | Published : 2022

DOI: 10.3758/s13415-022-00999-w

Abstract

Working memory deficits are common in attention-deficit/hyperactivity disorder (ADHD) and depression—two common neurodevelopmental disorders with overlapping cognitive profiles but distinct clinical presentation. Multivariate techniques have previously been utilized to understand working memory processes in functional brain networks in healthy adults but have not yet been applied to investigate how working memory processes within the same networks differ within typical and atypical developing populations. We used multivariate pattern analysis (MVPA) to identify whether brain networks discriminated between spatial versus verbal working memory processes in ADHD and Persistent Depressive Disord..

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University of Melbourne Researchers

Alasdair Vance Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This research was conducted within the Developmental Imaging research group, Murdoch Children's Research Institute and the Academic Child Psychiatry Unit, Department of Paediatrics, The University of Melbourne. Royal Children's Hospital, Melbourne, Victoria. It was supported by the Murdoch Children's Research Institute, the Royal Children's Hospital, The Royal Children's Hospital Foundation, Department of Paediatrics, The University of Melbourne, and the Victorian Government's Operational Infrastructure Support Program. TS was supported by a NHMRC Career Development Award. DY was supported by the National Institutes of Health NRSA Fellowship F31-DA042574. The authors thank all children and families who participated in this research. They also thank Dr. Lauren Richmond and Dr. Alec Solway for helpful comments and suggestions on the manuscript. DY and VV thank the Kavli Foundation for enabling participation in their Summer School in Cognitive Neuroscience (2016, Santa Barbara, CA), where this collaboration originated.