Genetic variants associated with longitudinal changes in brain structure across the lifespan

RM Brouwer; M Klein; KL Grasby; HG Schnack; N Jahanshad; J Teeuw; SI Thomopoulos; E Sprooten; CE Franz; N Gogtay; WS Kremen; MS Panizzon; LM Olde Loohuis; CD Whelan; M Aghajani; C Alloza; D Alnæs; E Artiges; R Ayesa-Arriola; GJ Barker; ME Bastin; E Blok; E Bøen; IA Breukelaar; JK Bright; EEL Buimer; R Bülow; DM Cannon; S Ciufolini; NA Crossley; CG Damatac; P Dazzan; CL de Mol; SMC de Zwarte; S Desrivières; CM Díaz-Caneja; NT Doan; K Dohm; JH Fröhner; J Goltermann; A Grigis; D Grotegerd; LKM Han; MA Harris; CA Hartman; SJ Heany; W Heindel; DJ Heslenfeld; S Hohmann; B Ittermann; PR Jansen; J Janssen; T Jia; J Jiang; C Jockwitz; T Karali; D Keeser; MGJC Koevoets; RK Lenroot; B Malchow; RCW Mandl; V Medel; S Meinert; CA Morgan; TW Mühleisen; L Nabulsi; N Opel; VOG de la Foz; BJ Overs; ML Paillère Martinot; R Redlich; TR Marques; J Repple; G Roberts; GV Roshchupkin; N Setiaman; E Shumskaya; F Stein; G Sudre; S Takahashi; A Thalamuthu; D Tordesillas-Gutiérrez; A van der Lugt; NEM van Haren; JM Wardlaw; W Wen; HJ Westeneng; K Wittfeld; AH Zhu; A Zugman; NJ Armstrong; G Bonfiglio; J Bralten; S Dalvie; G Davies; M Di Forti; L Ding; G Donohoe; AJ Forstner; J Gonzalez-Peñas

Journal article

Genetic variants associated with longitudinal changes in brain structure across the lifespan

RM Brouwer, M Klein, KL Grasby, HG Schnack, N Jahanshad, J Teeuw, SI Thomopoulos, E Sprooten, CE Franz, N Gogtay, WS Kremen, MS Panizzon, LM Olde Loohuis, CD Whelan, M Aghajani, C Alloza, D Alnæs, E Artiges, R Ayesa-Arriola, GJ Barker Show all

Nature Neuroscience | NATURE PORTFOLIO | Published : 2022

DOI: 10.1038/s41593-022-01042-4

Abstract

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression..

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