Journal article
A Pathway-Based Genetic Score for Oxidative Stress: An Indicator of Host Vulnerability to Phthalate-Associated Adverse Neurodevelopment
S Tanner, S Thomson, K Drummond, M O’hely, C Symeonides, T Mansell, R Saffery, PD Sly, F Collier, D Burgner, EJ Sugeng, T Dwyer, P Vuillermin, AL Ponsonby
Antioxidants | MDPI | Published : 2022
Open access
Abstract
The developing brain is highly sensitive to environmental disturbances, and adverse exposures can act through oxidative stress. Given that oxidative stress susceptibility is determined partly by genetics, multiple studies have employed genetic scores to explore the role of oxidative stress in human disease. However, traditional approaches to genetic score construction face a range of challenges, including a lack of interpretability, bias towards the disease outcome, and often overfitting to the study they were derived on. Here, we develop an alternative strategy by first generating a genetic pathway function score for oxidative stress (gPFSox ) based on the transcriptional activity levels of..
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Funding Acknowledgements
Funding was secured from National Health and Medical Research Council of Australia (NHMRC), The Minderoo Foundation, The Shepherd Foundation, The Jack Brockhoff Foundation, the Scobie and Claire McKinnon Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fund Raising Committee Barwon Health, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA, Vanguard Investments Australia Ltd., and the Percy Baxter Charitable Trust, Perpetual Trustees. In-kind support was provided by the Cotton on Foundation and CreativeForce. The study sponsors were not involved in the collection, analysis, and interpretation of data; writing of the report; or the decision to submit the report for publication. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.