Journal article
Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy
RJ Phang, RH Ritchie, DJ Hausenloy, JG Lees, SY Lim
Cardiovascular Research | OXFORD UNIV PRESS | Published : 2023
DOI: 10.1093/cvr/cvac049
Abstract
Patients with Type 2 diabetes mellitus (T2DM) frequently exhibit a distinctive cardiac phenotype known as diabetic cardiomyopathy. Cardiac complications associated with T2DM include cardiac inflammation, hypertrophy, fibrosis, and diastolic dysfunction in the early stages of the disease, which can progress to systolic dysfunction and heart failure. Effective therapeutic options for diabetic cardiomyopathy are limited and often have conflicting results. The lack of effective treatments for diabetic cardiomyopathy is due in part, to our poor understanding of the disease development and progression, as well as a lack of robust and valid preclinical human models that can accurately recapitulate ..
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Awarded by National Medical Research Council
Funding Acknowledgements
This work was supported by grants from the St Vincent's Hospital (Melbourne) Research Endowment Fund, Stafford Fox Medical Research Foundation, St Vincent's Institute Rising Star Award, and infrastructure funding from the Victorian Government (Australia) Operational Infrastructure Support Scheme to St Vincent's Institute of Medical Research. D.J.H. is supported by the Duke-NUS Signature Research Programme funded by the Ministry of Health, Singapore Ministry of Health's National Medical Research Council under its Clinician Scientist-Senior Investigator scheme (NMRC/CSA-SI/0011/2017), Centre Grant (CGAug16M006), and Collaborative Centre Grant scheme (NMRC/CGAug16C006).