Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis: An International Registry Study

M Vitkova; I Diouf; C Malpas; D Horakova; E Kubala Havrdova; F Patti; S Ozakbas; G Izquierdo; S Eichau; V Shaygannejad; M Onofrj; A Lugaresi; R Alroughani; A Prat; C Larochelle; M Girard; P Duquette; M Terzi; C Boz; F Grand'maison; P Sola; D Ferraro; P Grammond; H Butzkueven; K Buzzard; O Skibina; BI Yamout; R Karabudak; O Gerlach; J Lechner-Scott; D Maimone; R Bergamaschi; V Van Pesch; G Iuliano; E Cartechini; M José Sà; R Ampapa; M Barnett; SE Hughes; CM Ramo-Tello; S Hodgkinson; DLA Spitaleri; T Petersen; EG Butler; M Slee; C McGuigan; PA McCombe; F Granella; E Cristiano; J Prevost; BV Taylor; JL Sãnchez-Menoyo; G Laureys; L Van Hijfte; S Vucic; RA MacDonell; O Gray; J Olascoaga; N Deri; YD Fragoso; C Shaw; T Kalincik

Journal article

Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis: An International Registry Study

M Vitkova, I Diouf, C Malpas, D Horakova, E Kubala Havrdova, F Patti, S Ozakbas, G Izquierdo, S Eichau, V Shaygannejad, M Onofrj, A Lugaresi, R Alroughani, A Prat, C Larochelle, M Girard, P Duquette, M Terzi, C Boz, F Grand'maison Show all

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2022

DOI: 10.1212/WNL.0000000000200545

Abstract

Background and ObjectivesThe severity of multiple sclerosis (MS) varies widely among individuals. Understanding the determinants of this heterogeneity will help clinicians optimize the management of MS. The aim of this study was to investigate the association between latitude of residence, UV B radiation (UVB) exposure, and the severity of MS.MethodsThis observational study used the MSBase registry data. The included patients met the 2005 or 2010 McDonald diagnostic criteria for MS and had a minimum dataset recorded in the registry (date of birth, sex, clinic location, date of MS symptom onset, disease phenotype at baseline and censoring, and ≥1 Expanded Disability Status Scale score recorde..

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University of Melbourne Researchers

Ibrahima Diouf Author

Charles Malpas Author

Richard MacDonell Author

Tomas Kalincik Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported by National Health and Medical Research Council (1140766, 1129189, 1157717). Marianna Vitkova is supported by a visiting research fellowship provided by Biogen. The MSBase Foundation is a not-for-profit organization that receives support from Biogen, Novartis, Merck, Roche, Teva, and Sanofi Genzyme. The study was conducted separately and apart from the guidance of the sponsors.