Journal article
Molecular Basis of Functional Effects of Phosphorylation of the C-Terminal Domain of the Rabies Virus P Protein
J Zhan, E Watts, AM Brice, RD Metcalfe, AM Rozario, A Sethi, F Yan, TDM Bell, MDW Griffin, GW Moseley, PR Gooley
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2022
DOI: 10.1128/jvi.00111-22
Abstract
The rabies virus (RABV) phosphoprotein (P protein) is expressed as several isoforms, which differ in nucleocytoplasmic localization and microtubule (MT) association, mediated by several sequences, including nuclear localization (NLS) and export (NES) sequences. This appears to underpin a functional diversity enabling multiple functions in viral replication and modulation of host biology. Mechanisms regulating trafficking are poorly defined, but phosphorylation by protein kinase C (PKC) in the P protein C-terminal domain (PCTD) regulates nuclear trafficking, mediated by PCTD-localized NLS/NES sequences, indicating that phosphorylation contributes to functional diversity. The molecular mechani..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
This study was supported by National Health and Medical Research Council grant 1125704 to G.W.M. and P.R.G. and grants 1160838 and 1079211 to G.W.M.; Australian Research Council grants DP210100998 to P.R.G. and G.W.M., DP170104477 to T.D.M.B., and DP150102569 to G.W.M.; and a Grimwade Fellowship provided by the Meigunyah Fund to G.W.M. Parts of this research were conducted at the MX2 beamline of the Australian Synchrotron, part of the Australian Nuclear Science and Technology Organization and made use of the ACRF Detector.