Journal article
The Optimal Target and Connectivity for Deep Brain Stimulation in Lennox–Gastaut Syndrome
AEL Warren, LJ Dalic, KJ Bulluss, AR BAppSci, W Thevathasan, JS Archer
Annals of Neurology | WILEY | Published : 2022
DOI: 10.1002/ana.26368
Abstract
Objective: Deep brain stimulation (DBS) can reduce seizures in Lennox–Gastaut syndrome (LGS). However, little is known about the optimal target and whether efficacy depends on connectivity of the stimulation site. Using outcome data from the ESTEL trial, we aimed to determine the optimal target and connectivity for DBS in LGS. Methods: A total of 20 patients underwent bilateral DBS of the thalamic centromedian nucleus (CM). Outcome was percentage seizure reduction from baseline after 3 months of DBS, defined using three measures (monthly seizure diaries, 24-hour scalp electroencephalography [EEG], and a novel diary-EEG composite). Probabilistic stimulation mapping identified thalamic locatio..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank the patients and their families for participating. This work was supported by funding from the National Health and Medical Research Council (project grant #1108881). AELW was supported by a post-doctoral fellowship from the Lennox-Gastaut syndrome Foundation and an Early Career Researcher Grant from the University of Melbourne. LJD was supported by an Australian Government Research Training Program Scholarship. This research was supported by the University of Melbourne's Research Computing Services and the Petascale Campus Initiative.