Use of a buprenorphine-based pain management protocol is associated with reduced opioid requirements and pain on swallowing in oral mucositis: a retrospective cohort study

Abstract

Objective: The aim of this study is to ascertain the analgesic efficacy and total oral morphine equivalent daily dose (OMEDD) effect of a buprenorphine-based analgesic protocol in the treatment of severe Oral Mucositis (OM). Design: This is a retrospective cohort study. Setting: This study was done in a single Quaternary Referral Centre, Haematology Unit. Subjects: Fifty-four stem cell transplant patients suffering at least grade 3 oral mucositis (OM), 24 prior to [Pr-I] and 30 subsequent to [Po-I] a buprenorphine-based OM analgesic protocol. Methods: We analysed data from the above subjects with the primary outcome measure of difference in total OMEDDs from all opioid types and administrati..