Journal article
Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study
K O’Flaherty, JA Chan, JC Cutts, SG Zaloumis, EA Ashley, AP Phyo, DR Drew, AM Dondorp, NP Day, M Dhorda, RM Fairhurst, P Lim, C Amaratunga, S Pukrittayakamee, TT Hien, Y Htut, M Mayxay, MA Faiz, OA Mokuolu, MA Onyamboko Show all
Frontiers in Cellular and Infection Microbiology | Published : 2022
Abstract
Introduction: Understanding the human immune response to Plasmodium falciparum gametocytes and its association with gametocytemia is essential for understanding the transmission of malaria as well as progressing transmission blocking vaccine candidates. Methods: In a multi-national clinical efficacy trial of artemisinin therapies (13 sites of varying transmission over South-East Asia and Africa), we measured Immunoglobulin G (IgG) responses to recombinant P. falciparum gametocyte antigens expressed on the gametocyte plasma membrane and leading transmission blocking vaccine candidates Pfs230 (Pfs230c and Pfs230D1M) and Pfs48/45 at enrolment in 1,114 participants with clinical falciparum malar..
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