Journal article
Shortened Infant Telomere Length Is Associated with Attention Deficit/Hyperactivity Disorder Symptoms in Children at Age Two Years: A Birth Cohort Study
C Pham, R Vryer, M O’hely, T Mansell, D Burgner, F Collier, C Symeonides, MLK Tang, P Vuillermin, L Gray, R Saffery, AL Ponsonby
International Journal of Molecular Sciences | Published : 2022
DOI: 10.3390/ijms23094601
Abstract
Environmental factors can accelerate telomere length (TL) attrition. Shortened TL is linked to attention deficit/hyperactivity disorder (ADHD) symptoms in school-aged children. The onset of ADHD occurs as early as preschool-age, but the TL-ADHD association in younger children is unknown. We investigated associations between infant TL and ADHD symptoms in children and assessed environmental factors as potential confounders and/or mediators of this association. Relative TL was measured by quantitative polymerase chain reaction in cord and 12-month blood in the birth cohort study, the Barwon Infant Study. Early life environmental factors collected antenatally to two years were used to measure c..
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Awarded by Percy Baxter Charitable Trust
Funding Acknowledgements
The establishment work and infrastructure for the Barwon Infant Study (BIS) was provided by the Murdoch Children's Research Institute, Deakin University, and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia, The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fundraising Committee of Barwon Health, the Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited, and the Percy Baxter Charitable Trust, Perpetual Trustees, and the Minderoo Foundation. In-kind support was provided by the Cotton On Foundation and CreativeForce. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. C. Pham is supported by a Melbourne Children's Campus LifeCourse PhD Support Program scholarship, funded by the Royal Children's Hospital Foundation grant #2018-984. R. Vryer is supported by a University of Melbourne PhD stipend. This work was also supported by an NHMRC Investigator Grant (APP1197234 to A.L. Ponsonby).