Journal article
miR-155-overexpressing monocytes resemble HLAhighISG15 synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4 T-cell activation
AM Olsson, GAM Povoleri, D Somma, ML Ridley, T Rizou, S Lalnunhlimi, L MacDonald, M Rajasekhar, RT Martinez-Nunez, M Kurowska-Stolarska, LS Taams
Clinical and Experimental Immunology | Published : 2022
DOI: 10.1093/cei/uxab016
Abstract
MicroRNAs (miRs) are known to regulate pro-inflammatory effector functions of myeloid cells, and miR dysregulation is implicated in rheumatoid arthritis (RA), a condition characterized by inflammation and destruction of the joints. We showed previously that miR-155 is increased in myeloid cells in RA and induces pro-inflammatory activation of monocytes and macrophages; however, its role at the interface between innate and adaptive immunity was not defined. Here, RNA-sequencing revealed that overexpression of miR-155 in healthy donor monocytes conferred a specific gene profile which bears similarities to that of RA synovial fluid-derived CD14+ cells and HLAhighISG15+ synovial tissue macrophag..
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Awarded by National Institute for Health and Care Research
Funding Acknowledgements
This work was supported by Versus Arthritis (grant no. 20960 to support A.M.O. and L.S.T.; grant no. 21139 to support G.A.M.P., M.L.R., S.L., and L.S.T.; grant no. 22272 to support M.K.-S.), the Research into Inflammatory Arthritis Centre Versus Arthritis (RACE; grant no. 22072 to support M.K.-S. and L.M.); and a GSK grant to support D.S. This study was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London and/or the NIHR Clinical Research Facility. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care.