Journal article
Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria
SI Studniberg, LJ Ioannidis, RAS Utami, L Trianty, Y Liao, W Abeysekera, CSN Li-Wai-Suen, HM Pietrzak, J Healer, AM Puspitasari, D Apriyanti, F Coutrier, JR Poespoprodjo, E Kenangalem, B Andries, P Prayoga, N Sariyanti, GK Smyth, AF Cowman, RN Price Show all
Molecular Systems Biology | SPRINGERNATURE | Published : 2022
Abstract
Clinical immunity to P. falciparum malaria is non-sterilizing, with adults often experiencing asymptomatic infection. Historically, asymptomatic malaria has been viewed as beneficial and required to help maintain clinical immunity. Emerging views suggest that these infections are detrimental and constitute a parasite reservoir that perpetuates transmission. To define the impact of asymptomatic malaria, we pursued a systems approach integrating antibody responses, mass cytometry, and transcriptional profiling of individuals experiencing symptomatic and asymptomatic P. falciparum infection. Defined populations of classical and atypical memory B cells and a TH2 cell bias were associated with re..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). Supported by the Australian Government National Health and Medical Research Council (NHMRC) Independent Medical Research Institutes Infrastructure Support Scheme and Project Grants 1058665 and 1137989; the Australian Academy of Science (DSH), the Victorian State Government Operational Infrastructure Support, and the Ministry of Research and Technology of the Republic of Indonesia. GKS was supported by NHMRC Fellowship 1154970.