Journal article
Side-effects of analgesic kyotorphin derivatives: Advantages over clinical opioid drugs
MMB Ribeiro, SS Santos, DSC Sousa, M Oliveira, SM Santos, M Heras, E Bardaji, I Tavares, MARB Castanho
Amino Acids | SPRINGER WIEN | Published : 2013
Abstract
The adverse side-effects associated with opioid administration restrain their use as analgesic drugs and call for new solutions to treat pain. Two kyotorphin derivatives, kyotorphin-amide (KTP-NH2) and ibuprofen-KTP-NH2 (IbKTP-NH2) are promising alternatives to opioids: they trigger analgesia via an indirect opioid mechanism and are highly effective in several pain models following systemic delivery. In vivo side-effects of KTP-NH2 and IbKTP-NH2 are, however, unknown and were evaluated in the present study using male adult Wistar rats. For comparison purposes, morphine and tramadol, two clinically relevant opioids, were also studied. Results showed that KTP-derivatives do not cause constipat..
View full abstractGrants
Awarded by European Commission
Funding Acknowledgements
We thank Autonomic Nervous System Unit and Neurosciences Unit from Instituto de Medicina Molecular (Portugal), especially Prof. I. Rocha, Prof. A. Sebastiao and Dr. L. Lopes for the support, helpful discussions and facilities provided. Manuel N. Melo is thanked for critical revision of the manuscript. Fundacao para a Ciencia e Tecnologia (Portugal) is acknowledged for funding: SFRH/BD/42158/2007 fellowship to M. Ribeiro and SFRH/BI/51213/2010 fellowship (for doctorate) to S. Sa Santos associated to Marie Curie IAPP. Marie Curie Industry-Academia Partnerships and Pathways (European Commission) is also acknowledged for funding (FP7-PEOPLE-2007-3-1-IAPP. Project 230654). The authors acknowledge and appreciate the financial support received from Faculdade de Medicina da Universidade de Lisboa and Fundacao Amadeu Dias, Portugal (Project No. 2010029).