Seizure Forecasting by High-Frequency Activity (80-170 Hz) in Long-term Continuous Intracranial EEG Recordings

Abstract

Background and ObjectivesReliable seizure forecasting has important implications in epilepsy treatment and improving the quality of lives for people with epilepsy. High-frequency activity (HFA) is a biomarker that has received significant attention over the past 2 decades, but its predictive value in seizure forecasting remains uncertain. This work aimed to determine the utility of HFA in seizure forecasting.MethodsWe used seizure data and HFA (80-170 Hz) data obtained from long-term, continuous intracranial EEG recordings of patients with drug-resistant epilepsy. Instantaneous rates and phases of HFA cycles were used as features for seizure forecasting. Seizure forecasts based on each indiv..