Journal article
Tamoxifen affects the histology and hepatopancreatic lipid metabolism of swimming crab Portunus trituberculatus
M Liu, Q Feng, DS Francis, GM Turchini, C Zeng, X Wu
Aquatic Toxicology | Published : 2019
Abstract
Tamoxifen (TAM) is an antiestrogenic agent and can enter the aquatic environment in wastewater. It has been reported that TAM can induce hepatic steatosis in vertebrates, however, the effects of TAM exposure on lipid metabolism of hepatopancreas in crustaceans remains unclear. In this study, four TAM concentrations (0, 6.7, 13.4 and 20 μg g−1 crab body weight) were injected into the swimming-leg of swimming crabs Portunus trituberculatus, as a means of evaluating the effects of TAM on the expression levels of lipid metabolism-related genes, lipid composition, and hepatopancreas histology. The results showed that the mRNA levels of three lipogenic related genes (diacylglycerol acyltransferase..
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Awarded by National Natural Science Foundation of China
Funding Acknowledgements
This study was funded by the two projects (No. 41276158 and No. 41606169) from the Natural Science Foundation of China. Analysis costs were partially supported a research and extension project (No. 2016-1-18) from Shanghai Agriculture Committee and a special research project (No. SZ-LYG2017019) for North Jiangsu area from Science and Technology Department of Jiangsu Province and. Infrastructure costs were partially supported by the research project (No. A1-2801-18-1003) for high level university in Shanghai from Shanghai Education Commission and Collaborative Innovation Project for Mari-culture industry in East China Sea from Ningbo University.