Journal article
Cortico-Striatal Activity Characterizes Human Safety Learning via Pavlovian Conditioned Inhibition
PAF Laing, T Steward, CG Davey, KL Felmingham, MA Fullana, B Vervliet, MD Greaves, B Moffat, RK Glarin, BJ Harrison
Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2022
Abstract
Safety learning generates associative links between neutral stimuli and the absence of threat, promoting the inhibition of fear and security-seeking behaviors. Precisely how safety learning is mediated at the level of underlying brain systems, particularly in humans, remains unclear. Here, we integrated a novel Pavlovian conditioned inhibition task with ultra-high field (7 Tesla) fMRI to examine the neural basis of safety learning in 49 healthy participants. In our task, participants were conditioned to two safety signals: a conditioned inhibitor that predicted threat omission when paired with a known threat signal (A+/AX-), and a standard safety signal that generally predicted threat omissi..
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Awarded by University of Minnesota
Funding Acknowledgements
This work was supported by National Health and Medical Research Council of Australia Project Grant 1161897 to B.J.H. T.S. was supported by National Health and Medical Research Council of Australia-MRFF Investigator Grant MRF1193736, a BBRF Young Investigator Grant, and the University of Melbourne McKenzie Fellowship. We acknowledge the scientific and technical assistance of the Australian National Imaging Facility, a National Collaborative Research Infrastructure Strategy capability at the Melbourne Brain Center Imaging Unit, University of Melbourne. The multiband fMRI sequence was generously supported by a research collaboration agreement with CMRR, the University of Minnesota; the MP2RAGE works in progress sequence was provided by Siemens Healthineers (Germany). We thank Lisa Incerti for contributions to data collection.