Journal article
Can brain signals and anatomy refine contact choice for deep brain stimulation in Parkinson's disease?
SS Xu, WL Lee, T Perera, NC Sinclair, KJ Bulluss, HJ McDermott, W Thevathasan
Journal of Neurology Neurosurgery and Psychiatry | Published : 2022
Abstract
Introduction Selecting the ideal contact to apply subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease is time-consuming and reliant on clinical expertise. The aim of this cohort study was to assess whether neuronal signals (beta oscillations and evoked resonant neural activity (ERNA)), and the anatomical location of electrodes, can predict the contacts selected by long-term, expert-clinician programming of STN-DBS. Methods We evaluated 92 hemispheres of 47 patients with Parkinson's disease receiving chronic monopolar and bipolar STN-DBS. At each contact, beta oscillations and ERNA were recorded intraoperatively, and anatomical locations were assessed. How these factor..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was funded through the National Health and Medical Research Council (Development grant number 1177815, project grant number 1 103 238 (Bionics Institute), post graduate scholarship number 1 133 295 (SS.X)), St Vincent's Hospital Research Endowment Fund and Colonial Foundation. WT is also supported through Lions International. All authors affiliated with the Bionics Institute acknowledge the support it receives from the Victorian Government through its operational infrastructure programme.