Journal article
Preclinical safety study of a fully implantable, sub-scalp ring electrode array for long-term EEG recordings
YB Benovitski, A Lai, A Saunders, CC McGowan, O Burns, DAX Nayagam, R Millard, M Harrison, GD Rathbone, RA Williams, CN May, M Murphy, WJ D'Souza, MJ Cook, CE Williams
Journal of Neural Engineering | IOP Publishing Ltd | Published : 2022
Abstract
Objective. Long-term electroencephalogram (EEG) recordings can aid diagnosis and management of various neurological conditions such as epilepsy. In this study we characterize the safety and stability of a clinical grade ring electrode arrays by analyzing EEG recordings, fluoroscopy, and computed tomography (CT) imaging with long-term implantation and histopathological tissue response. Approach. Seven animals were chronically implanted with EEG recording array consisting of four electrode contacts. Recordings were made bilaterally using a bipolar longitudinal montage. The array was connected to a fully implantable micro-processor controlled electronic device with two low-noise differential am..
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Awarded by Thyne Reid Foundation
Funding Acknowledgements
[ "The authors acknowledge the current financial support from Epiminder Pty Ltd, and earlier support from the Australian National Health and Medical Research Council Project Grant (APP1075347), and Thyne Reid Foundation (Perpetual financial services). The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program.", "The funding sources had no involvement in study design, collection, analysis and interpretation of data, writing of the report, or the decision to submit the article for publication." ]