Journal article
Prevalence, risk factors, and prognosis of drug-resistant epilepsy in autoimmune encephalitis
R Wesselingh, J Broadley, K Buzzard, D Tarlinton, U Seneviratne, C Kyndt, J Stankovich, P Sanfilippo, C Nesbitt, W D'Souza, R Macdonell, H Butzkueven, TJ O'Brien, M Monif
Epilepsy and Behavior | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2022
Abstract
Objective: To evaluate the prevalence and biomarkers of drug-resistant epilepsy (DRE) in patients with autoimmune encephalitis (AIE). Methods: Sixty-nine patients with AIE were recruited retrospectively and electroencephalographies (EEGs) were reviewed using a standard reporting proforma. Associations between EEG biomarkers and DRE development at 12 months were examined using logistic regression modeling and were utilized to create a DRE risk score. Results: Sixteen percent of patients with AIE developed DRE at 12-month follow-up. The presence of status epilepticus (SE) (OR 11.50, 95% CI [2.81, 51.86], p-value <0.001), temporal lobe focality (OR 9.90, 95% CI [2.60, 50.71], p-value 0.001) and..
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Funding Acknowledgements
We acknowledge the contributions made by Callum Hollis, Ramja Kokulan, Patrick Carney, Annie Roten, and John Archer for their assistance in the procurement and review of EEG data, and the Australian Autoimmune Encephalitis Consortium for their support of the project.