Journal article
Association of pneumococcal carriage in infants with the risk of carriage among their contacts in Nha Trang, Vietnam: A nested cross-sectional survey
G Qian, M Toizumi, S Clifford, LT Le, T Papastylianou, C Satzke, B Quilty, C Iwasaki, N Kitamura, M Takegata, MX Bui, HAT Nguyen, DA Dang, AJ van Hoek, LM Yoshida, S Flasche
Plos Medicine | PUBLIC LIBRARY SCIENCE | Published : 2022
Open access
Abstract
Background Infants: are at highest risk of pneumococcal disease. Their added : protection through herd effects is a key part in the considerations on optimal pneumococcal vaccination strategies. Yet, little is currently known about the main transmission pathways to this vulnerable age group. Hence, this study investigates pneumococcal transmission routes to infants in the coastal city of Nha Trang, Vietnam. Methods and findings In October 2018, we conducted a nested cross-sectional contact and pneumococcal carriage survey in randomly selected 4- to 11-month-old infants across all 27 communes of Nha Trang. Bayesian logistic regression models were used to estimate age specific carriage prevale..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
SF, SC and the infant contact survey were supported by a Sir Henry Dale Fellowship awarded to SF jointly funded by the Wellcome Trust and the Royal Society (Grant number:208812/Z/17/Z). LMY, MT, CS, GQ, BQ and the pneumococcal carriage survey of the Nha Trang PCV reduced dosing study is funded by the Bill & Melinda Gates Foundation (Grant number:OPP1139859). The Nha Trang population-based cohort study was supported by AMED under Grant Number JP21wm0125006. CS was supported by an Australian NHMRC Career Development Fellowship and a Veski Inspiring Women Fellowship. MCRI was supported by the Victorian Government's Operational Infrastructure Support Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.