Journal article
Infant inflammation predicts childhood emotional and behavioral problems and partially mediates socioeconomic disadvantage
C Pham, S Bekkering, M O'Hely, D Burgner, S Thomson, P Vuillermin, F Collier, W Marx, T Mansell, C Symeonides, PD Sly, MLK Tang, R Saffery, AL Ponsonby
Brain Behavior and Immunity | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2022
Abstract
Background: Emotional and behavioral problems (EBP) are common in children. Environmental factors like socioeconomic disadvantage influence EBP pathogenesis and can trigger inflammation. However, the link between early inflammation-EBP in children is unclear. We investigated the associations between i) infant inflammatory biomarkers and subsequent EBP and ii) early life environmental factors and EBP and assessed whether infant inflammation mediated these associations. Methods: Inflammatory biomarkers glycoprotein acetyls (GlycA) and high-sensitivity C-reactive protein (hsCRP) were quantified at birth and 12 months in a population–derived birth cohort, the Barwon Infant Study. Early life fact..
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Awarded by Jack Brockhoff Foundation
Funding Acknowledgements
The authors thank the Barwon Infant Study participants for the generous contribution they have made to this study. We thank Terry Dwyer for his role in the original BIS Steering Committee. The establishment work and infrastructure for the BIS was provided by the Murdoch Children's Research Institute, Deakin University and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia, The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's FundRaising Committee Barwon Health, The Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited and the Percy Baxter Charitable Trust, Perpetual Trustees, and the Minderoo Foundation. In-kind support was provided by the Cotton On Foundation and CreativeForce. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. C Pham is supported by a Melbourne Children's Campus LifeCourse PhD Support Program scholarship, funded by Royal Children's Hospital Foundation grant number 2018-984. S Bekkering is funded by the Dutch Research Council [Rubicon grant number 452173113] and the Dutch Heart Foundation [2018T028]. This work was also supported by NHMRC, Australia Investigator Grants [APP1197234 to AL Ponsonby; APP1175744 D Burgner]. The BIS Investigator Group consists of Sarath Ranganathan, Lawrence Gray and Amy Loughman. Thanks to Sam Song, Alex Eisner, Steph Glynn and Georgia Cotter for proofreading the paper.