Journal article
Multi-omics analysis from archival neonatal dried blood spots: Limitations and opportunities
YJ Zhuang, Y Mangwiro, M Wake, R Saffery, RF Greaves
Clinical Chemistry and Laboratory Medicine | Published : 2022
Abstract
Newborn screening (NBS) programs operate in many countries, processing millions of dried bloodspot (DBS) samples annually. In addition to early identification of various adverse health outcomes, these samples have considerable potential as a resource for population-based research that could address key questions related to child health. The feasibility of archival DBS samples for emerging targeted and untargeted multi-omics analysis has not been previously explored in the literature. This review aims to critically evaluate the latest advances to identify opportunities and challenges of applying omics analyses to NBS cards in a research setting. Medline, Embase and PubMed databases were searc..
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Funding Acknowledgements
The Victorian Newborn Bloodspot Screening Program is funded by the Department of Health Victoria with additional funding support from the Victorian Clinical Genetics Services. Generation Victoria is supported by the Paul Ramsay Foundation, the Victorian Government, the Murdoch Children's Research Institute and the Royal Children's Hospital Foundation. Research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.