Journal article
Genomic epidemiology of Salmonella Typhi in Central Division, Fiji, 2012 to 2016
MR Davies, S Duchene, M Valcanis, AP Jenkins, A Jenney, V Rosa, AJ Hayes, AG Strobel, L McIntyre, JA Lacey, EJ Klemm, VK Wong, A Sahukhan, H Thomson, A Page, D Hocking, N Wang, L Tudravu, E Rafai, G Dougan Show all
Lancet Regional Health Western Pacific | Published : 2022
Abstract
Background: Typhoid fever is endemic in some Pacific Island Countries including Fiji and Samoa yet genomic surveillance is not routine in such settings. Previous studies suggested imports of the global H58 clade of Salmonella enterica var Typhi (Salmonella Typhi) contribute to disease in these countries which, given the MDR potential of H58, does not auger well for treatment. The objective of the study was to define the genomic epidemiology of Salmonella Typhi in Fiji. Methods: Genomic sequencing approaches were implemented to study the distribution of 255 Salmonella Typhi isolates from the Central Division of Fiji. We augmented epidemiological surveillance and Bayesian phylogenomic approach..
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Awarded by State Government of Victoria
Funding Acknowledgements
This work was supported by the Coalition Against Typhoid through the Bill and Melinda Gates Foundation [grant number OPP1017518] , the Victorian Government, the National Health and Medical Research Council Australia, the Australian Research Council, and the Fiji Ministry of Health and Medical Services.