Journal article
Lung ultrasound of the dependent lung detects real-time changes in lung volume in the preterm lamb
A Sett, KR Kenna, RJ Sutton, EJ Perkins, M Sourial, JD Chapman, SM Donath, A Sasi, SR Rogerson, BJ Manley, PG Davis, PM Pereira-Fantini, DG Tingay
Archives of Disease in Childhood Fetal and Neonatal Edition | BMJ PUBLISHING GROUP | Published : 2022
Open access
Abstract
Background Effective lung protective ventilation requires reliable, real-time estimation of lung volume at the bedside. Neonatal clinicians lack a readily available imaging tool for this purpose. Objective To determine the ability of lung ultrasound (LUS) of the dependent region to detect real-time changes in lung volume, identify opening and closing pressures of the lung, and detect pulmonary hysteresis. Methods LUS was performed on preterm lambs (n=20) during in vivo mapping of the pressure-volume relationship of the respiratory system using the super-syringe method. Electrical impedance tomography was used to derive regional lung volumes. Images were blindly graded using an expanded scori..
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Awarded by Royal Children's Hospital Foundation
Funding Acknowledgements
This study is supported by the Victorian Government Operational Infrastructure Support Program (Melbourne, Australia) and a grant from the National Health and Medical Research Council (NHMRC; Grant ID 1182676). AS is supported by a research grant from the Australasian Society of Ultrasound in Medicine and a PhD scholarship from the Centre of Research Excellence in Newborn Medicine, Victoria. DGT is supported by a Royal Children's Hospital Foundation Clinical Scientist Fellowship and an NHMRC Investigator (Grant ID 2008212). PGD is supported by an NHMRC Practitioner Fellowship (Grant ID 556600). BJM is supported by a Medical Research Future Fund (Australia) Fellowship Grant (Grant ID 1159225). GE Healthcare provided the Logiq E ultrasound system but were not involved in study design, analysis, or interpretation of results.