Journal article
Effect of Surgical Humidification on Inflammation and Peritoneal Trauma in Colorectal Cancer Surgery: A Randomized Controlled Trial
S Sampurno, T Chittleborough, M Dean, M Flood, S Carpinteri, S Roth, RM Millen, H Cain, JCH Kong, J MacKay, SK Warrier, J McCormick, JG Hiller, AG Heriot, RG Ramsay, AC Lynch
Annals of Surgical Oncology | Published : 2022
Abstract
Background: Pre-clinical studies indicate that dry-cold-carbon-dioxide (DC-CO2) insufflation leads to more peritoneal damage, inflammation and hypothermia compared with humidified-warm-CO2 (HW-CO2). Peritoneum and core temperature in patients undergoing colorectal cancer (CRC) surgery were compared. Methods: Sixty-six patients were randomized into laparoscopic groups; those insufflated with DC-CO2 or HW-CO2. A separate group of nineteen patients undergoing laparotomy were randomised to conventional surgery or with the insertion of a device delivering HW-CO2. Temperatures were monitored and peritoneal biopsies and bloods were taken at the start of surgery, at 1 and 3 h. Further bloods were ta..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
Fisher and Paykel Healthcare (F&PHC) provided laboratory support for this study and the humidification device (HumiGardTM) and tubing sets central to conducting this RCT. F&PHC provided technical support, most particularly Jessica Fogarin and Michael Blackhurst noting they were not engaged in data collection or analysis. Epworth Healthcare and PMCC provided research support. RGR and AGH receive research support from the National Health and Medical Research Council, Australia (Grant No. APP1156391).