Journal article
The ‘Danse Macabre’—Neutrophils the Interactive Partner Affecting Oral Cancer Outcomes
S Hadjigol, BA Shah, NM O’Brien-Simpson
Frontiers in Immunology | Published : 2022
Abstract
Over the past few decades, tremendous advances in the prevention, diagnosis, and treatment of cancer have taken place. However for head and neck cancers, including oral cancer, the overall survival rate is below 50% and they remain the seventh most common malignancy worldwide. These cancers are, commonly, aggressive, genetically complex, and difficult to treat and the delay, which often occurs between early recognition of symptoms and diagnosis, and the start of treatment of these cancers, is associated with poor prognosis. Cancer development and progression occurs in concert with alterations in the surrounding stroma, with the immune system being an essential element in this process. Despit..
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Grants
Awarded by Australian Dental Research Foundation
Funding Acknowledgements
The National Health and Medical Research Council (NHMRC) of Australia and Australian Research Council (ARC) are thanked for financial support over many years for the immunology, microbiology, peptide chemistry and chemical biology studies reported in the authors laboratories. NOB-S is the recipient of NHMRC funding (APP1142472, APP1158841, APP1185426), ARC funding (DP210102781, DP160101312, LE200100163), Cancer Council Victoria funding (APP1163284), and the Australian Dental Research Foundation funding and research is supported by the Division of Basic and Clinical Oral Sciences and Centre for Oral Health Research at The Melbourne Dental School.