Journal article
MYL9 deficiency is neonatal lethal in mice due to abnormalities in the lung and the muscularis propria of the bladder and intestine
CH Huang, J Schuring, JP Skinner, L Mok, MMW Chong
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2022
Open access
Abstract
Class II myosin complexes are responsible for muscle contraction as well as other non-sarcomeric contractile functions in cells. Myosin heavy chain molecules form the core of these structures, while light chain molecules regulate their stability and function. MYL9 is a light chain isoform that is thought to regulate non-sarcomeric myosin. However, whether this in only in specific cell types or in all cells remains unclear. To address this, we generated MYL9 deficient mice. These mice die soon after birth with abnormalities in multiple organs. All mice exhibited a distended bladder, shortening of the small intestine and alveolar overdistension in the lung. The Myl9 allele in these mice includ..
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Awarded by U.S. Department of Defense
Funding Acknowledgements
This work was supported by grants and fellowships from the National Health and Medical Research Council, Australia (www.nhmrc.gov.au 1079586, 1117154, 1122384 and 1122395 to MMWC), Diabetes Australia (www.diabetesaustralia.com.au Y20G-CHOM to MMWC), U.S. Department of Defense (www.cdmrp.army.mil W81XWH-19-1-0728 to MMWC) and the Perpetual Foundation - The Ann Helene Toakley Charitable Endowment (www.perpetual.com.au to MMWC). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian National Health and Medical Research Council Research Institute Infrastructure Support Schemes. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.