Journal article
Impact of CPAP on the Atrial Fibrillation Substrate in Obstructive Sleep Apnea: The SLEEP-AF Study
CJ Nalliah, GR Wong, G Lee, A Voskoboinik, K Kee, J Goldin, T Watts, D Linz, R Parameswaran, H Sugumar, S Prabhu, A McLellan, LH Ling, SA Joseph, JB Morton, P Kistler, P Sanders, JM Kalman
Jacc Clinical Electrophysiology | Published : 2022
Abstract
Background: Observational studies report that obstructive sleep apnea (OSA) is associated with an increasingly remodeled atrial substrate in atrial fibrillation (AF). However, the impact of OSA management on the electrophysiologic substrate has not been evaluated. Objectives: In this study, the authors sought to determine the impact of OSA management on the atrial substrate in AF. Methods: We recruited 24 consecutive patients referred for AF management with at least moderate OSA (apnea-hypopnea index [AHI] ≥15). Participants were randomized in a 1:1 ratio to commence continuous positive airway pressure (CPAP) or no therapy (n = 12 CPAP; n = 12 no CPAP). All participants underwent invasive el..
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Funding Acknowledgements
For this work, Dr Nalliah received the Eric Prystowsky Fellows Clin- ical Research Award, Heart Rhythm Society, May 2020, and the Ralph Reader Young Investigator Prize of the Cardiac Society of Australia and New Zealand, December 2020; and he is supported also by the National Heart Foundation and a Viertel Charitable Foundation Clinical Investigator Award. Dr Voskoboinik is supported by an NHMRC EL1 Investigator Grant and an NHF Early Career Fellowship. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.