Journal article
Virology and immune dynamics reveal high household transmission of ancestral SARS-CoV-2 strain
S Tosif, ER Haycroft, S Sarkar, ZQ Toh, LAH Do, CM Donato, KJ Selva, M Hoq, I Overmars, J Nguyen, LY Lee, V Clifford, A Daley, FL Mordant, J McVernon, K Mulholland, AJ Marcato, MZ Smith, N Curtis, S McNab Show all
Pediatric Allergy and Immunology | Published : 2022
DOI: 10.1111/pai.13824
Abstract
Background: Household studies are crucial for understanding the transmission of SARS-CoV-2 infection, which may be underestimated from PCR testing of respiratory samples alone. We aim to combine the assessment of household mitigation measures; nasopharyngeal, saliva, and stool PCR testing; along with mucosal and systemic SARS-CoV-2–specific antibodies, to comprehensively characterize SARS-CoV-2 infection and transmission in households. Methods: Between March and September 2020, we obtained samples from 92 participants in 26 households in Melbourne, Australia, in a 4-week period following the onset of infection with ancestral SARS-CoV-2 variants. Results: The secondary attack rate was 36% (24..
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Awarded by National Institutes of Health
Funding Acknowledgements
Funding for the laboratory analysis and recruitment of participants were provided by the Royal Children's Hospital Foundation, DHB Foundation, and the Infection and Immunity Theme, MCRI. KK was supported by a NHMRC Investigator Grant (#1173871) and a Dame Kate Campbell Fellowship from The University of Melbourne.