Journal article
Anesthetic considerations in Dravet syndrome
E Macdonald-Laurs, S Corlette, A Davidson, KB Howell
Paediatric Anaesthesia | WILEY | Published : 2022
DOI: 10.1111/pan.14525
Abstract
We describe a two-year-old boy with Dravet syndrome, a severe genetic epilepsy, who developed a generalized tonic–clonic seizure immediately following an intravenous bolus of lidocaine given for propofol pain amelioration during induction of anesthesia for emergency gastroscopy. Although lidocaine has not specifically been reported as potentiating seizures in Dravet syndrome, it is well-established that sodium channel blockers can worsen seizures in this population.
Grants
Funding Acknowledgements
EML is supported by the Clifford Family PhD scholarship & Research Training Program PhD scholarship. SC is supported by Melbourne Children's Postgraduate Health Research Scholarship. KBH is supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship, an NHMRC Project Grant, and a Melbourne Children's Clinician Scientist Fellowship. The study was not industry--sponsored.