Inflammation and Epigenetic Aging Are Largely Independent Markers of Biological Aging and Mortality

L Cribb; AM Hodge; C Yu; SX Li; DR English; E Makalic; MC Southey; RL Milne; GG Giles; PA Dugu

Journal article

Inflammation and Epigenetic Aging Are Largely Independent Markers of Biological Aging and Mortality

L Cribb, AM Hodge, C Yu, SX Li, DR English, E Makalic, MC Southey, RL Milne, GG Giles, PA Dugu

Journals of Gerontology Series A Biological Sciences and Medical Sciences | OXFORD UNIV PRESS INC | Published : 2022

DOI: 10.1093/gerona/glac147

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Abstract

Limited evidence exists on the link between inflammation and epigenetic aging. We aimed to (a) assess the cross-sectional and prospective associations of 22 inflammation-related plasma markers and a signature of inflammaging with epigenetic aging and (b) determine whether epigenetic aging and inflammaging are independently associated with mortality. Blood samples from 940 participants in the Melbourne Collaborative Cohort Study collected at baseline (1990-1994) and follow-up (2003-2007) were assayed for DNA methylation and 22 inflammation-related markers, including well-established markers (eg, interleukins and C-reactive protein) and metabolites of the tryptophan-kynurenine pathway. Four me..

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University of Melbourne Researchers

Allison Hodge Author

Dallas English Author

Enes Makalic Author

Melissa Southey Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Melbourne Collaborative Cohort Study (MCCS) cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further augmented by Australian National Health and Medical Research Council grants 209057, 396414, and 1074383 and by infrastructure provided by Cancer Council Victoria. The nested case-control methylation studies were supported by the National Health and Medical Research Council grants 1011618, 1026892, 1027505, 1050198, 1043616, and 1074383. This work was further supported by National Health and Medical Research Council grants 1106016, 1088405, and 1164455. MCS is a National Health and Medical Research Council Senior Research Fellow (GNT1155163).