Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

A Elhakeem; AE Taylor; HM Inskip; J Huang; M Tafflet; JL Vinther; F Asta; JS Erkamp; L Gagliardi; K Guerlich; J Halliday; MW Harskamp-Van Ginkel; JR He; VWV Jaddoe; S Lewis; GM Maher; Y Manios; T Mansell; FP McCarthy; SW McDonald; E Medda; L Nisticò; AP De Moira; M Popovic; IKM Reiss; C Rodrigues; T Salika; A Smith; MA Stazi; C Walker; M Wu; BO Åsvold; H Barros; S Brescianini; D Burgner; JKY Chan; MA Charles; JG Eriksson; R Gaillard; V Grote; SE Håberg; B Heude; B Koletzko; S Morton; G Moschonis; D Murray; D O'Mahony; D Porta; X Qiu; L Richiardi; F Rusconi; R Saffery; SC Tough; TGM Vrijkotte; SM Nelson; AM Nybo Andersen; MC Magnus; DA Lawlor

Journal article

Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

A Elhakeem, AE Taylor, HM Inskip, J Huang, M Tafflet, JL Vinther, F Asta, JS Erkamp, L Gagliardi, K Guerlich, J Halliday, MW Harskamp-Van Ginkel, JR He, VWV Jaddoe, S Lewis, GM Maher, Y Manios, T Mansell, FP McCarthy, SW McDonald Show all

JAMA Network Open | Published : 2022

DOI: 10.1001/jamanetworkopen.2022.22106

Abstract

Importance: People conceived using assisted reproductive technology (ART) make up an increasing proportion of the world's population. Objective: To investigate the association of ART conception with offspring growth and adiposity from infancy to early adulthood in a large multicohort study. Design, Setting, and Participants: This cohort study used a prespecified coordinated analysis across 26 European, Asia-Pacific, and North American population-based cohort studies that included people born between 1984 and 2018, with mean ages at assessment of growth and adiposity outcomes from 0.6 months to 27.4 years. Data were analyzed between November 2019 and February 2022. Exposures: Conception by AR..

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University of Melbourne Researchers

Jane Halliday Author

Sharon Lewis Author

David Burgner Author

Richard Saffery Author

Grants

Awarded by European Commission

Funding Acknowledgements

This work was funded by the European Research Council under the European Union (EU) Horizon 2020 research and innovation program (agreements No. 101021566 [ART-HEALTH] and 733206 [LifeCycle]), the Medical Research Council (grant No. MC_UU_00011/6), British Heart Foundation (grants No. CH/F/20/90003 and AA/18/7/34219), and Bristol National Institute of Health Research Biomedical Research Centre (grant No. NF-0616-10102).