Journal article
Study protocol: Australasian Registry of Severe Cutaneous Adverse Reactions (AUS-SCAR)
F James, MSY Goh, E Mouhtouris, S Vogrin, KYL Chua, NE Holmes, A Awad, AM Copaescu, JF De Luca, C Zubrinich, D Gin, H Cleland, A Douglas, JS Kern, CH Katelaris, F Thien, S Barnes, J Yun, W Tong, WB Smith Show all
BMJ Open | BMJ PUBLISHING GROUP | Published : 2022
Open access
Abstract
Introduction Severe cutaneous adverse reactions (SCAR) are a group of T cell-mediated hypersensitivities associated with significant morbidity, mortality and hospital costs. Clinical phenotypes include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS) and acute generalised exanthematous pustulosis (AGEP). In this Australasian, multicentre, prospective registry, we plan to examine the clinical presentation, drug causality, genomic predictors, potential diagnostic approaches, treatments and long-term outcomes of SCAR in Australia and New Zealand. Methods and analysis Adult and adolescent patients with SCAR including ..
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Awarded by National Institutes of Health
Funding Acknowledgements
This research was funded by the Allergy and Immunology Foundation of Australasia (AIFA) and the Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne (Grant numbers not applicable).