Journal article
Effect of pneumococcal conjugate vaccine on prevalence of otitis media with effusion among children in Vietnam
M Toizumi, C Satoh, BJ Quilty, HAT Nguyen, L Madaniyazi, LT Le, CFS Ng, M Hara, C Iwasaki, M Takegata, N Kitamura, ML Nation, C Satzke, Y Kumai, HT Do, MX Bui, K Mulholland, S Flasche, DA Dang, K Kaneko Show all
Vaccine | Published : 2022
Abstract
Purpose: Otitis media with effusion (OME) is common in young children and is associated with Streptococcus pneumoniae infection. We aimed to determine the impact of pneumococcal conjugate vaccine (PCV) introduction on the prevalence of OME and OME associated with vaccine-type (VT) or non-VT. Methods: Population-based cross-sectional surveys were conducted in pre- (2016) and post-PCV periods (2017, 2018, and 2019) at selected communes in Nha Trang, Vietnam. For each survey, we randomly selected 60 children aged 4–11 months and 60 aged 14–23 months from each commune. Nasopharyngeal sample collection and tympanic membrane examination by digital otoscope were performed. S. pneumoniae was detecte..
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Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
This study was funded by the Joint Usage/Research Center on Tropical Disease, Institute of Tropical Medicine, Nagasaki University [grant number 28-Ippan-15; 29-Ippan-1; 2018-Ippan-8; 2019-Ippan-26] from Institute of Tropical Medicine, Nagasaki University; Japan Program for Infectious Diseases Research and Infrastructure, the Japan Agency for Medical Research and Development (AMED) [JP21wm0125006] ; and the Bill & Melinda Gates Foundation [OPP1399859] . We would like to thank the children and parents for their participation, staff from Khanh Hoa Health Service and National Institute of Hygiene and Epidemiology for their work in the field surveys, and Ms. Aiko Kaneko, Ms. Fumie Hara, and Dr. Sho Yoshida for their assistance of the ear examinations.