The impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis

JM Schwarzer; I Meyhoefer; LA Antonucci; L Kambeitz-Ilankovic; M Surmann; O Bienek; G Romer; U Dannlowski; T Hahn; A Korda; DB Dwyer; A Ruef; SS Haas; M Rosen; T Lichtenstein; S Ruhrmann; J Kambeitz; RKR Salokangas; C Pantelis; F Schultze-Lutter; E Meisenzahl; P Brambilla; A Bertolino; S Borgwardt; R Upthegrove; N Koutsouleris; R Lencer; A Hasan; C Hoff; I Khanyaree; A Melo; S Muckenhuber-Sternbauer; Y Köhler; Ö Öztürk; N Penzel; D Popovic; A Rangnick; S von Saldern; R Sanfelici; M Spangemacher; A Tupac; MF Urquijo; J Weiske; A Wosgien; C Krämer; K Blume; D Julkowski; N Kaden; R Milz; A Nikolaides; MS Vent; M Wassen; C Andreou; L Egloff; F Harrisberger; U Heitz; C Lenz; L Leanza; A Mackintosh; R Smieskova; E Studerus; A Walter; S Widmayer; C Day; SL Griffiths; M Iqbal; M Pelton; P Mallikarjun; A Stainton; A Lin; P Lalousis; A Denissoff; A Ellilä; T From; M Heinimaa; T Ilonen; P Jalo; H Laurikainen; A Luutonen; A Mäkela; J Paju; H Pesonen; RL Säilä; A Toivonen; O Turtonen; S Botterweck; N Kluthausen; G Antoch; J Caspers; HJ Wittsack; AB Solana; M Abraham; T Schirmer; C Altamura; M Belleri; F Bottinelli; A Ferro; M Re; E Monzani; M Sberna

Journal article

The impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis

JM Schwarzer, I Meyhoefer, LA Antonucci, L Kambeitz-Ilankovic, M Surmann, O Bienek, G Romer, U Dannlowski, T Hahn, A Korda, DB Dwyer, A Ruef, SS Haas, M Rosen, T Lichtenstein, S Ruhrmann, J Kambeitz, RKR Salokangas, C Pantelis, F Schultze-Lutter Show all

Neuropsychopharmacology | SPRINGERNATURE | Published : 2022

DOI: 10.1038/s41386-022-01385-3

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Abstract

Subtle subjective visual dysfunctions (VisDys) are reported by about 50% of patients with schizophrenia and are suggested to predict psychosis states. Deeper insight into VisDys, particularly in early psychosis states, could foster the understanding of basic disease mechanisms mediating susceptibility to psychosis, and thereby inform preventive interventions. We systematically investigated the relationship between VisDys and core clinical measures across three early phase psychiatric conditions. Second, we used a novel multivariate pattern analysis approach to predict VisDys by resting-state functional connectivity within relevant brain systems. VisDys assessed with the Schizophrenia Pronene..

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University of Melbourne Researchers

Dom Dwyer Author

Christos Pantelis Author

Alex Stainton Author

Grants

Awarded by Universität zu Köln

Funding Acknowledgements

The presented work was supported by the grant for the Personalized Prognostic Indicators for early Psychosis management (PRONIA Study): EU-FP7-HEALTH; agreement number: 602152. LK-I is a recipient of an NARSAD Young Investigator Award of the Brain & Behavior Research Foundation No. 28474. TL was additionally supported by the Koeln Fortune Program/Faculty of Medicine, University of Cologne. RL received additional funding from the European Unions Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 734227. Open Access funding enabled and organized by Projekt DEAL.