Journal article
Seizure control in successive pregnancies in Australian women with epilepsy
FJE Vajda, TJ O'Brien, J Graham, AA Hitchcock, P Perucca, CM Lander, MJ Eadie
Acta Neurologica Scandinavica | WILEY | Published : 2022
DOI: 10.1111/ane.13688
Abstract
Objectives: To investigate control of epileptic seizures during pairs of successive pregnancies in antiseizure medication (ASM)-treated women with epilepsy. Materials and Methods: Analysis of seizure freedom rates during 436 pairs of successive pregnancies in Australian women with epilepsy, in nearly all instances long-standing epilepsy. Result: There was a higher rate of seizure-free second pregnancies compared with first paired pregnancies (63.1% vs. 51.4%; Relative Risk (R.R.) = 1.2277; 95% CI 1.0930, 1.3789) and of seizure-free pre-pregnancy years before second as compared with first paired pregnancies in the same women (63.6% vs. 52.4%; R.R. = 1.2616; 95% CI 1.1337, 1.4040). In 108 wome..
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Awarded by Royal Melbourne Hospital Neuroscience Foundation
Funding Acknowledgements
We are grateful to professional and lay colleagues and to various bodies for referring patients to the APR, and also to the Scientific Advisory Board and the Ethical Research Committees of St. Vincent's Hospital, Monash Medical Centre, the Royal Melbourne Hospital and other relevant institutions for continuing ethics oversight of the APR. Over its years, The Epilepsy Society of Australia, The Royal Melbourne Hospital Neuroscience Foundation, Epilepsy Action Australia, the NHMRC and the pharmaceutical companies Sanofi-Aventis, UCB Pharma and Eisai and have provided financial support towards the maintenance of the APR. Open access publishing facilitated by The University of Melbourne, as part of the Wiley - The University of Melbourne agreement via the Council of Australian University Librarians.