Journal article
Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children
G Feng, L Kurtovic, PA Agius, EH Aitken, J Sacarlal, BD Wines, PM Hogarth, SJ Rogerson, FJI Fowkes, C Dobaño, JG Beeson
BMC Medicine | Published : 2022
Abstract
Background: RTS,S is the first malaria vaccine recommended for implementation among young children at risk. However, vaccine efficacy is modest and short-lived. Antibodies play the major role in vaccine-induced immunity, but knowledge on the induction, decay, and determinants of antibody function is limited, especially among children. Antibodies that promote opsonic phagocytosis and other cellular functions appear to be important contributors to RTS,S immunity. Methods: We studied a phase IIb trial of RTS,S/AS02 conducted in young children in malaria-endemic regions of Mozambique. We evaluated the induction of antibodies targeting the circumsporozoite protein (CSP, vaccine antigen) that inte..
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Awarded by United States Agency for International Development
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Program Grant and Senior Research Fellowship to JG Beeson; Project Grants to JG Beeson, and PM Hogarth), NHMRC Australian Centre for Research Excellence in Malaria Elimination (seed grant to G Feng), Australian Government Research Training Program Scholarship to LK. The Burnet Institute is supported by the NHMRC for Independent Research Institutes Infrastructure Support Scheme and the Victorian State Government Operational Infrastructure Support. JGB, GF, and LK are members of the NHMRC Australian Centre for Research Excellence in Malaria Elimination. CISM is supported by the Government of Mozambique and the Spanish Agency for International Development (AECID). This research was part of the ISGlobal's Program on the Molecular Mechanisms of Malaria, which is partially supported by the Fundacion Ramon Areces and we acknowledge support from the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa 2019-2023 Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program