Journal article
Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels
AE Au, J Corbin, M Lebois, P Gangatirkar, F Yassinson, SR Hyslop, P Cannon, KD Mason, CSN Li-Wai-Suen, AL Garnham, D Moujalled, L Cimmino, WS Alexander, EC Josefsson
Blood Advances | ELSEVIER | Published : 2023
Abstract
Platelets have been shown to enhance the survival of lymphoma cell lines. However, it remains unclear whether they play a role in lymphoma. Here, we investigated the potential role of platelets and/or megakaryocytes in the progression of Eμ-myc lymphoma. Eμ-myc tumor cells were transplanted into recipient wild-type (WT) control, Mpl−/−, or TpoTg mice, which exhibited normal, low, and high platelet and megakaryocyte counts, respectively. TpoTg mice that underwent transplantation exhibited enhanced lymphoma progression with increased white blood cell (WBC) counts, spleen and lymph node weights, and enhanced liver infiltration when compared with WT mice. Conversely, tumor-bearing Mpl−/− mice ha..
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Funding Acknowledgements
This work was generously supported by grant funds received from the following sources: Leukaemia Foundation Australia Grant-in-Aid (E.C.J. and K.D.M.), Sir Edward Dunlop Medical Research Foundation (E.C.J.), a project grant from the CASS Foundation (A.E.A.), the National Health and Medical Research Council of Australia Project (1079250) (E.C.J.) and Program (1113577) Grants and Fellowship (1058344) (W.S. A.), an Independent Research Institutes Infrastructure Support Scheme Grant ( 9000587), and a Victorian State Government Operational Infrastructure Support Grant. E.C.J. is the recipient of a fellowship from the Lorenzo and Pamela Galli Charitable Trust. S.R.H. is the recipient of an Australian Postgraduate Award from the University of Melbourne.