Journal article
Intestinal microbiota regulates diabetes and cancer progression by IL-1β and NOX4 dependent signaling cascades
M Noureldein, R Nawfal, S Bitar, SS Maxwell, I Khurana, HK Kassouf, FR Khuri, A El-Osta, AA Eid
Cellular and Molecular Life Sciences | SPRINGER BASEL AG | Published : 2022
Abstract
Diabetes changes the host microbiota, a condition known as dysbiosis. Dysbiosis is an important factor for the pathogenesis of diabetes and colorectal cancer (CRC). We aimed at identifying the microbial signature associated with diabetes and CRC; and identifying the signaling mechanism altered by dysbiosis and leading to CRC progression in diabetes. MKR mice that can spontaneously develop type 2 diabetes were used. For CRC induction, another subset of mice was treated with azoxymethane and dextran sulfate sodium. To identify the role of microbiota, microbiota-depleted mice were inoculated with fecal microbial transplant from diabetic and CRC mice. Further, a mouse group was treated with prob..
View full abstractGrants
Funding Acknowledgements
MN is supported by a doctoral fellowship from the American University of Beirut, Faculty of Medicine. This study is supported by a regular research grant from the American University of Beirut Medical Practice Plan and a regular research grant (National Priority Research Project) from the Qatar National Research Foundation for AAE.